Compassionate Allowances In Social Security Disability Claims
Compassionate Allowances
Compassionate Allowances Can Allow Your SSDI Or SSI Claim To Be Fast-Tracked
When a serious medical condition makes it impossible to work, the wait for a Social Security disability decision can feel unbearable. Compassionate Allowances exists to shorten that wait for the people who need it most. It's a Social Security Administration (SSA) program that can fast-track an SSDI or SSI claim when a qualifying condition is severe enough, and well documented enough, to leave little doubt.
This guide explains what Compassionate Allowances is, which conditions currently qualify, how the fast-track process works, and what to do next if you or someone you love may be eligible.
Key Takeaways (UPDATED: August 19, 2026)
- Compassionate Allowances (CAL) is an SSA program that speeds up the medical decision on an SSDI or SSI claim for the most severe, well-documented conditions.
- CAL does not change the benefit amount or the eligibility rules. It only changes how fast SSA can approve the medical part of a claim.
- As of SSA's August 2026 update, 314 conditions are on the CAL list, including aggressive cancers, certain adult brain disorders, and rare pediatric conditions.
- Being on the list does not guarantee approval. The claimant still has to meet SSA's disability standard and submit strong medical evidence.
- The standard 5-month SSDI waiting period and 24-month Medicare waiting period still apply, even after a fast-tracked approval.
What Is the Compassionate Allowances Program?
Compassionate Allowances, often shortened to CAL, is a Social Security Administration (SSA) program that started in 2008. It flags certain disability applications for a faster medical decision when the applicant's condition is severe enough, and well documented enough, to clearly meet SSA's disability standard.
CAL is not a separate benefit. It doesn't add money to a claim, and it doesn't create a new type of payment. It changes one thing only: how quickly SSA can approve the medical part of an SSDI or SSI claim. According to the National Council on Aging (NCOA), more than 1.1 million people have been approved through the program since it began.
How Compassionate Allowances Fast-Tracks an SSDI or SSI Claim
When someone applies for Social Security disability benefits, SSA checks the diagnosed condition against the official Compassionate Allowances list. If it's a match, the claim gets flagged for priority medical review. In SSA's own words, the program helps reduce waiting time to reach a disability determination.
Compassionate Allowances applies to both SSDI and SSI claims, since both programs use the same medical definition of disability. The two programs differ only in how they're funded and who qualifies financially: SSDI is based on work history, and SSI is based on income and resources. This is different than the standard SSDI and SSI eligibility requirements.
CAL Is Not the Same as Quick Disability Determination (QDD)
SSA also runs a second, related fast-track process called Quick Disability Determination, or QDD. The two get confused often, but they work differently.
Compassionate Allowances flags a claim because the diagnosis appears on a specific, published list. Quick Disability Determination uses a predictive computer model that scans the entire claim file for patterns suggesting a favorable decision is highly likely, and it isn't tied to any fixed list of conditions. Neither program requires a separate application. Both simply move an eligible claim ahead in the queue.
Compassionate Allowances vs. Quick Disability Determination
| Compassionate Allowances (CAL) | Quick Disability Determination (QDD) | |
|---|---|---|
| What triggers it | A condition on SSA's published CAL list | A predictive model applied during initial review |
| Tied to a fixed, named list | Yes, 314 conditions as of SSA's August 2026 update | No, not limited to a published list |
| Applies to | SSDI and SSI | SSDI and SSI |
| Separate application needed | No | No |
| Who flags it | SSA's system, based on the diagnosis on file | SSA's model, based on patterns across the claim file |
Why Some Claims Move Faster Than Others
A standard disability claim moves through the same steps as every other application: medical evidence collection, review by the state disability agency, and, if needed, reconsideration and a hearing. A CAL-flagged claim skips ahead in that line once the medical evidence is on file, because SSA already knows the condition meets a high severity bar.
Standard Review vs. Compassionate Allowances Review
| Stage | Standard SSDI or SSI review | Compassionate Allowances review |
|---|---|---|
| Initial decision | Typically 1 to 4 months | Flagged as soon as SSA identifies the listed condition for priority medical review |
| Reconsideration, if needed | Typically 1 to 3 months | Uncommon; most CAL-flagged claims with strong evidence are approved at the initial level |
| Hearing, if needed | A year or more | Uncommon for CAL-flagged claims with strong evidence |
| Total, start to decision | Often 18 to 24 months for a claim that needs an appeal | Substantially faster once flagged and documented |
| Extra application required | No | No, same standard application |
| Benefit amount if approved | Set by standard SSDI/SSI rules | Same. CAL does not change the benefit amount |
| SSDI 5-month waiting period | Applies | Still applies |
| Medicare 24-month wait (SSDI) | Applies | Still applies |
Here's what that process looks like in practice, from application to determination:
1. Application submitted → 2. CAL condition identified → 3. Medical evidence reviewed → 4. Determination issued
The Compassionate Allowances List: Which Conditions Qualify
314 conditions on the current Compassionate Allowances list (SSA, August 2026)
As of SSA's August 2026 update, the Compassionate Allowances list includes 314 conditions. SSA reviews and expands the list on an ongoing basis, often using input from medical professionals and patient advocacy groups.
Here are the general categories CAL covers:
- Aggressive and rare cancers
- Adult brain disorders, including certain forms of early-onset dementia
- Rare genetic and neurological disorders that affect infants and children
- Amyotrophic Lateral Sclerosis (ALS) and similar rapidly progressive neurological conditions
Recently Added Compassionate Allowances Conditions
On August 11, 2026, SSA added 14 new conditions to the Compassionate Allowances list, bringing the total to 314. SSA adds to the list periodically, so it's worth checking the current version rather than assuming an older list is still accurate. Here are the newly added conditions:
- Adenylosuccinate Lyase Deficiency – Neonatal Form and Type 1
- Aicardi Syndrome
- Baraitser-Winter Syndrome
- Beare-Stevenson Cutis Gyrata Syndrome
- Bohring-Opitz Syndrome
- CASK-Related Gene Disorders
- Hepatosplenic T-Cell Lymphoma
- Lafora Disease
- Malignant Migrating Partial Seizures of Infancy (MMPSI)
- OPHN1 Syndrome
- Primary Cardiac Sarcoma
- Primary Intracranial Malignant Melanoma
- Uveal Melanoma – with Metastases
- Warburg Micro Syndrome
If you have one of these 14 diagnoses and a claim already pending, this matters right now. A claim filed before August 11, 2026 was screened against the old list. Contact Social Security — or contact Quikaid and we will do it for you — to make sure your file is re-flagged for expedited handling.
Common Categories of Qualifying Conditions
Most conditions on the list fall into a few broad groups: cancers, particularly advanced or specific subtypes; adult brain disorders; rare pediatric genetic and neurological disorders; and rapidly progressive conditions like ALS.
Am I Eligible for Compassionate Allowances?
Two things have to be true for a claim to qualify for Compassionate Allowances.
Standard Review vs. Compassionate Allowances Review
| Part | What it means |
|---|---|
| 1. The condition is on SSA's official CAL list | Confirmed against SSA's current published list, not a lookalike or related condition |
| 2. Medical evidence supports it | Diagnosis and severity are documented, and the claimant otherwise meets SSA's disability standard |
Being close to a listed condition isn't the same as being on it. SSA is specific about what qualifies, sometimes down to the stage or subtype of a disease. Chronic Myelogenous Leukemia, for example, is on the Compassionate Allowances list only in its blast phase, the most advanced stage. An earlier-stage diagnosis of the same disease doesn't automatically qualify for CAL, even though it may still qualify for standard disability benefits.
The claimant also has to meet SSA's basic disability standard, which includes not currently doing what SSA calls substantial gainful activity. For 2026, that limit is $1,690 a month for most applicants, or $2,830 a month for applicants who are blind.
What We See in Practice:
Quikaid's disability specialists review Compassionate Allowances claims regularly, and one documentation gap comes up more than any other. The diagnosis is on file, but the specific stage, subtype, or severity marker SSA needs to confirm the match isn't clearly documented yet. A claim can list the right condition and still get delayed if the medical records don't spell out the detail that makes it a match.
How to Apply for a Compassionate Allowances Claim
There's no separate Compassionate Allowances application. A claimant applies for SSDI or SSI the normal way, online, by phone, or in person, and makes sure the qualifying condition and diagnosis are clearly stated.
Documentation That Helps SSA Identify a CAL Claim Faster
- The exact diagnosis, written the way it appears on the Compassionate Allowances list, including stage or subtype where SSA requires one
- Records from the diagnosing physician or specialist, not just a primary care note
- Any biopsy, imaging, or lab results that confirm the diagnosis
- A clear statement of when the condition was diagnosed and how it has progressed
Common Mistakes That Slow Down a Compassionate Allowances Claim
- Listing a general condition name instead of the specific diagnosis SSA needs
- Submitting an application before diagnostic records are available
- Leaving gaps in medical treatment that make it harder for SSA to confirm severity
- Assuming the claim was automatically flagged and not following up if it stalls
A representative can help make sure a claim is coded and flagged correctly from the start, which matters more on a CAL claim than a standard one, since the whole benefit of the program depends on SSA recognizing the match right away.
What Happens After Approval
An approval through Compassionate Allowances speeds up the decision, not the payment timeline. Two waiting periods still apply.
SSDI benefits start after a standard five-month waiting period, counted from the date SSA determines the disability began. Medicare coverage for SSDI recipients has its own separate waiting period, typically 24 months from the start of benefit eligibility, and Compassionate Allowances doesn't shorten it.
If a claim has been pending for a while, back pay may be owed for the months before approval, going back to the date SSA determines the disability began. Back pay is separate from the ongoing monthly benefit and is paid once, after approval.
What If a Compassionate Allowances Claim Is Denied?
60 days to appeal a denial
Receiving a denial is unfortunately part of the process for many claimants, even ones with a condition on the Compassionate Allowances list. However, everyone has the right to appeal. This is one step where it can be extremely helpful to have an experienced representative in your corner.
Claimants generally have 60 days to file an appeal after a denial. SSA builds in a five-day grace period, and beyond that, a late appeal can still be accepted if the claimant shows good cause for the delay, such as a hospitalization. Even so, it's best to treat the 60 days as a real deadline and act quickly rather than count on the grace period.
How Quikaid Can Help With a Compassionate Allowances Claim
Quikaid is a Social Security disability representation firm, not a law firm, and its team includes both licensed attorneys and SSA-authorized non-attorney representatives who focus exclusively on SSDI and SSI claims. Since 1993, Quikaid has helped over 250,000 people pursue the disability benefits they've earned.
For a Compassionate Allowances claim specifically, the biggest risk usually isn't eligibility, it's documentation. A claim can list the right condition and still move slowly if the medical records don't clearly establish the stage, subtype, or severity SSA needs to confirm the match. Quikaid's team helps build a claim that's correctly documented and properly flagged from the start.
People who work with an experienced representative are statistically more likely to be approved for disability benefits than those who go through the process alone.
No upfront cost. Pay only if you win. Fees are capped by federal law.
There's no retainer and no hourly billing, and Quikaid can provide guidance right away.
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The Bottom Line
Compassionate Allowances can fast-track an SSDI or SSI claim for the most severe, well-documented conditions. It won't guarantee approval, and it won't speed up the waiting periods that follow, but for the right claim, it can mean the difference between a decision measured in weeks instead of one that takes a year or more.
If you believe a condition may qualify, don't wait to find out. It's free, there's no obligation, and it only takes about a minute to get started.
All SSDI and SSI claims are subject to Social Security Administration review and approval. Past results do not guarantee future outcomes. Quikaid's fee is regulated by the SSA and only applies if your claim is approved. The free case evaluation is provided with no obligation.
Frequently Asked Questions (FAQs)
What's the difference between Compassionate Allowances and a regular disability claim?
Compassionate Allowances speeds up the medical decision on a claim. It doesn't change the benefit amount, and it doesn't change SSA's eligibility rules. A CAL-flagged claim and a standard claim are judged by the same disability standard, just on a faster timeline.
How many conditions are on the Compassionate Allowances list?
As of SSA's August 2026 update, 314 conditions are on the list. SSA reviews and updates the list periodically, so it's worth checking SSA's current, official list rather than relying on an older count.
Does Compassionate Allowances guarantee approval?
No. A condition on the Compassionate Allowances list still has to be backed by medical evidence that supports the diagnosis and its severity, and the claimant still has to meet SSA's disability standard. Being on the list speeds up the review. It doesn't replace it.
What is the difference between Compassionate Allowances and Quick Disability Determination (QDD)?
Both are SSA fast-track programs, but they work differently. Compassionate Allowances applies to a fixed, published list of conditions. Quick Disability Determination uses a predictive computer model to flag claims across a broader range of severe cases, without being limited to a specific list.
Is Compassionate Allowances the same as SSDI?
No. Compassionate Allowances is a review process, not a benefit program on its own. It can apply to either an SSDI claim or an SSI claim.
Can you get Compassionate Allowances for SSI?
Yes. Compassionate Allowances applies to both SSDI and SSI claims, since both use the same medical definition of disability.
Do I need a lawyer for a Compassionate Allowances claim?
Not necessarily, and Quikaid isn't a law firm. It's a disability representation firm whose team includes both licensed attorneys and SSA-authorized non-attorney representatives who focus only on Social Security disability claims. A representative isn't required, but people who use one are statistically more likely to be approved for disability benefits than those who apply alone.
This article has been reviewed and approved by Quikaid staff, many of whom previously worked at the Social Security Administration in leadership positions within the disability adjudication process.
External Sources Cited In This Article:
- SSA, Compassionate Allowances news release, August 11, 2026
- SSA, official Compassionate Allowances conditions list (PDF, 314 conditions, updated August 10, 2026)
- SSA, Fast-Track Processes overview
- SSA, Quick Disability Determinations
- SSA, 2026 Red Book, Substantial Gainful Activity figures
- NCOA, Compassionate Allowances program and eligibility
- USA.gov, Social Security disability benefits overview
The Full List Of Compassionate Allowances Conditions - 2026:
0–9
- 1p36 Deletion Syndrome
A
- Acute Leukemia
- Adenylosuccinate Lyase Deficiency – Neonatal Form and Type 1
- Adrenal Cancer – with Distant Metastases or Inoperable, Unresectable, or Recurrent
- Adult Heart Transplant Wait List – Status Levels 1-4
- Adult Non-Hodgkin Lymphoma
- Adult Onset Huntington Disease
- Aicardi-Goutieres Syndrome
- Aicardi Syndrome
- Alexander Disease (ALX) – Neonatal and Infantile
- Allan-Herndon-Dudley Syndrome
- Alobar Holoprosencephaly
- Alpers Disease
- Alpha Mannosidosis – Types II and III
- ALS/Parkinsonism Dementia Complex
- Alstrom Syndrome
- Alveolar Soft Part Sarcoma
- Amegakaryocytic Thrombocytopenia
- Amyotrophic Lateral Sclerosis (ALS) – Adult
- Anaplastic Adrenal Cancer – Adult with Distant Metastases or Inoperable, Unresectable or Recurrent
- Anaplastic Ependymoma
- Anaplastic Thyroid Cancer
- Angelman Syndrome
- Angioimmunoblastic T-Cell Lymphoma
- Angiosarcoma
- Aortic Atresia
- Aplastic Anemia
- Astrocytoma – Grade III and IV
- Ataxia Telangiectasia
- Atypical Teratoid/Rhabdoid Tumor
- Au-Kline Syndrome
B
- Bainbridge-Ropers Syndrome
- Baraitser-Winter Syndrome
- Batten Disease
- Beare-Stevenson Cutis Gyrata Syndrome
- Beta Thalassemia Major
- Bilateral Anophthalmia
- Bilateral Optic Atrophy – Infantile
- Bilateral Retinoblastoma
- Bladder Cancer – with Distant Metastases or Inoperable or Unresectable
- Blastic Plasmacytoid Dendritic Cell Neoplasm
- Bohring-Opitz Syndrome
- Breast Cancer – with Distant Metastases or Recurrent
C
- CACH – Vanishing White Matter Disease – Congenital, Infantile, and Early Childhood Onset Forms
- Calciphylaxis
- Canavan Disease (CD)
- Carcinoma of Unknown Primary Site
- Cardiac Amyloidosis – AL Type
- Carey-Fineman-Ziter Syndrome
- CASK-Related Gene Disorders
- Caudal Regression Syndrome – Types III and IV
- CDKL5 Deficiency Disorder
- Cerebro Oculo Facio Skeletal (COFS) Syndrome
- Cerebrotendinous Xanthomatosis
- Charlevoix-Saguenay Spastic Ataxia
- Child Heart Transplant Wait List – Status Levels 1A/1B
- Child Lymphoblastic Lymphoma
- Child Lymphoma
- Child Medulloblastoma
- Child Neuroblastoma – with Distant Metastases or Recurrent
- Child T-Cell Lymphoblastic Lymphoma
- Cholangiocarcinoma
- Chondrosarcoma – with Multimodal Therapy
- Choroid Plexus Carcinoma
- Chronic Idiopathic Intestinal Pseudo Obstruction
- Chronic Myelogenous Leukemia (CML) – Blast Phase
- CIC-rearranged Sarcoma
- Coffin-Lowry Syndrome
- Congenital Lymphedema
- Congenital Myotonic Dystrophy
- Congenital Zika Syndrome
- Cornelia de Lange Syndrome – Classic Form
- Corticobasal Degeneration
- Costello Syndrome
- Creutzfeldt-Jakob Disease (CJD) – Adult
- Cri du Chat Syndrome
D
- Degos Disease – Systemic
- De Sanctis Cacchione Syndrome
- Desmoplastic Mesothelioma
- Desmoplastic Small Round Cell Tumors
- Dravet Syndrome
- Duchenne Muscular Dystrophy – Adult
E
- Edwards Syndrome (Trisomy 18)
- Eisenmenger Syndrome
- Endometrial Stromal Sarcoma
- Endomyocardial Fibrosis
- Ependymoblastoma (Child Brain Cancer)
- Erdheim Chester Disease
- Esophageal Cancer
- Esthesioneuroblastoma
- Ewing Sarcoma
F
- Farber Disease (FD) – Infantile
- Fatal Familial Insomnia
- Fibrodysplasia Ossificans Progressiva
- Fibrolamellar Cancer
- Follicular Dendritic Cell Sarcoma – Metastatic or Recurrent
- FOXG1 Syndrome
- Friedreich's Ataxia (FRDA)
- Frontotemporal Dementia (FTD), Pick's Disease – Type A – Adult
- Fryns Syndrome
- Fucosidosis – Type I
- Fukuyama Congenital Muscular Dystrophy
- Fulminant Giant Cell Myocarditis
G
- Galactosialidosis – Early and Late Infantile Types
- Gallbladder Cancer
- Gaucher Disease (GD) – Type 2
- Gerstmann-Straussler-Scheinker Disease
- Giant Axonal Neuropathy
- Glioblastoma Multiforme (Adult Brain Cancer)
- Glioma – Grade III and IV
- Glutaric Acidemia – Type II
- GM1 – Gangliodosis – Infantile and Juvenile Forms
H
- Harlequin Ichthyosis – Child
- Head and Neck Cancers – with Distant Metastasis or Inoperable or Unresectable
- Heart Transplant Graft Failure
- Hematopoietic Stem Cell Transplantation
- Hemophagocytic Lymphohistiocytosis – Familial Type (FHLH)
- Hepatoblastoma
- Hepatocellular Carcinoma
- Hepatopulmonary Syndrome
- Hepatorenal Syndrome
- Hepatosplenic T-Cell Lymphoma
- Histiocytic Malignancies
- Histiocytosis Syndromes
- Hoyeraal-Hreidarsson Syndrome
- Hutchinson-Gilford Progeria Syndrome
- Hydranencephaly
- Hypocomplementemic Urticarial Vasculitis Syndrome
- Hypophosphatasia – Perinatal (Lethal) and Infantile Onset Types
- Hypoplastic Left Heart Syndrome
I
- I Cell Disease
- Idiopathic Pulmonary Fibrosis
- Infantile Free Sialic Acid Storage Disease
- Infantile Neuroaxonal Dystrophy (INAD)
- Infantile Neuronal Ceroid Lipofuscinoses
- Inflammatory Breast Cancer (IBC)
- Intracranial Hemangiopericytoma
J
- Jervell and Lange-Nielsen Syndrome
- Joubert Syndrome
- Junctional Epidermolysis Bullosa – Lethal Type
- Juvenile Onset Huntington Disease
K
- Kidney Cancer – Inoperable or Unresectable
- Kleefstra Syndrome
- Krabbe Disease (KD) – Infantile
- Kufs Disease – Type A and B
L
- Lafora Disease
- Large Intestine Cancer – with Distant Metastasis or Inoperable, Unresectable or Recurrent
- Late Infantile Neuronal Ceroid Lipofuscinoses
- Leber Congenital Amaurosis
- Leigh's Disease
- Leiomyosarcoma
- Leptomeningeal Carcinomatosis
- Lesch-Nyhan Syndrome (LNS)
- Lewy Body Dementia
- Liposarcoma – Metastatic or Recurrent
- Lissencephaly
- LMNA-related Congenital Muscular Dystrophy
- Lowe Syndrome
- Lymphomatoid Granulomatosis – Grade III
M
- Malignant Brainstem Gliomas – Childhood
- Malignant Ectomesenchymoma
- Malignant Gastrointestinal Stromal Tumor
- Malignant Germ Cell Tumor
- Malignant Migrating Partial Seizures of Infancy (MMPSI)
- Malignant Multiple Sclerosis
- Malignant Renal Rhabdoid Tumor
- Mantle Cell Lymphoma (MCL)
- Maple Syrup Urine Disease
- Marshall-Smith Syndrome
- Mastocytosis Type IV
- MECP2 Duplication Syndrome
- Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
- Megalencephaly-Capillary Malformation Syndrome
- Menkes Disease – Classic or Infantile Onset Form
- Merkel Cell Carcinoma – with Metastases
- Merosin Deficient Congenital Muscular Dystrophy
- Metachromatic Leukodystrophy (MLD) – Late Infantile
- Metastatic Endometrial Adenocarcinoma
- Microvillus Inclusion Disease – Child
- Mitral Valve Atresia
- Mixed Dementias
- Mowat-Wilson Syndrome
- MPS I
- MPS II
- MPS III
- Mucosal Malignant Melanoma
- Multicentric Castleman Disease
- Multiple System Atrophy
- Myelodysplastic Syndrome with Excess Blasts
- Myoclonic Epilepsy with Ragged Red Fibers Syndrome
N
- Neonatal Adrenoleukodystrophy
- Neonatal Marfan Syndrome
- Nephrogenic Systemic Fibrosis
- Neurodegeneration with Brain Iron Accumulation – Types 1 and 2
- NFU-1 Mitochondrial Disease
- Nicolaides-Baraitser Syndrome
- Niemann-Pick Disease (NPD) – Type A
- Niemann-Pick Disease – Type C
- Nonketotic Hyperglycinemia
- Non-Small Cell Lung Cancer
- NUT Carcinoma
O
- Obliterative Bronchiolitis
- Ohtahara Syndrome
- Oligodendroglioma Brain Cancer – Grade III
- OPHN1 Syndrome
- Ornithine Transcarbamylase (OTC) Deficiency
- Orthochromatic Leukodystrophy with Pigmented Glia
- Osteogenesis Imperfecta (OI) – Type II
- Osteosarcoma, Formerly Known as Bone Cancer
- Ovarian Cancer – with Distant Metastases or Inoperable or Unresectable
P
- PACS1 Syndrome
- Pallister-Killian Syndrome
- Pancreatic Cancer
- Paraneoplastic Cerebellar Degeneration
- Paraneoplastic Pemphigus
- Patau Syndrome (Trisomy 13)
- Pearson Syndrome
- Pelizaeus-Merzbacher Disease – Classic Form
- Pelizaeus-Merzbacher Disease – Connatal Form
- Pericardial Mesothelioma
- Peripheral Nerve Cancer – Metastatic or Recurrent
- Peritoneal Mesothelioma
- Peritoneal Mucinous Carcinomatosis
- Perry Syndrome
- Pfeiffer Syndrome – Types II and III
- Phelan-McDermid Syndrome
- Pineoblastoma – Childhood
- Pitt-Hopkins Syndrome
- Plasmablastic Lymphoma
- Pleural Mesothelioma
- Pompe Disease – Infantile
- Pontocerebellar Hypoplasia
- Posterior Cortical Atrophy
- Primary Cardiac Sarcoma
- Primary Central Nervous System Lymphoma
- Primary Effusion Lymphoma
- Primary Intracranial Malignant Melanoma
- Primary Omental Cancer
- Primary Peritoneal Cancer
- Primary Progressive Aphasia
- Progressive Bulbar Palsy
- Progressive Multifocal Leukoencephalopathy
- Progressive Muscular Atrophy
- Progressive Supranuclear Palsy
- Prostate Cancer – Hormone Refractory Disease – or with Visceral Metastases
- Pulmonary Amyloidosis – AL Type
- Pulmonary Atresia
- Pulmonary Kaposi Sarcoma
R
- Rasmussen Encephalitis
- Refractory Hodgkin Lymphoma
- Renal Amyloidosis – AL Type
- Renal Medullary Carcinoma
- Renpenning Syndrome
- Retinopathy of Prematurity – Stage V, Bilateral
- Rett (RTT) Syndrome
- Revesz Syndrome
- Rhabdomyosarcoma
- Rhizomelic Chondrodysplasia Punctata
- Richter Syndrome
- Roberts Syndrome
- Rubinstein-Taybi Syndrome
S
- Salivary Cancers
- Sandhoff Disease
- Sarcomatoid Carcinoma of the Lung – Stages II-IV
- Sarcomatoid Mesothelioma
- Schindler Disease – Type I
- SCN8A-related Epilepsy with Encephalopathy
- Seckel Syndrome
- Secondary Adenocarcinoma of the Brain
- Severe Combined Immunodeficiency – Childhood
- Single Ventricle
- Sinonasal Cancer
- Sjogren-Larsson Syndrome
- Skin Malignant Melanoma – with Metastases
- Small Cell Cancer of the Female Genital Tract
- Small Cell Cancer of the Large Intestine
- Small Cell Cancer of the Ovary
- Small Cell Cancer of the Prostate
- Small Cell Cancer of the Thymus
- Small Cell Lung Cancer
- Small Intestine Cancer – with Distant Metastases or Inoperable, Unresectable or Recurrent
- Smith Lemli Opitz Syndrome
- Snijders Blok-Campeau Syndrome
- Soft Tissue Sarcoma – with Distant Metastases or Recurrent
- Spinal Muscular Atrophy (SMA) – Types 0 and 1
- Spinal Nerve Root Cancer – Metastatic or Recurrent
- Spinocerebellar Ataxia
- Stiff Person Syndrome
- Stomach Cancer – with Distant Metastases or Inoperable, Unresectable or Recurrent
- Subacute Sclerosing Panencephalitis
- Superficial Siderosis of the Central Nervous System
- SYNGAP1-Related NSID
T
- Tabes Dorsalis
- Tay Sachs Disease – Infantile Type
- Taybi-Linder Syndrome
- Tetrasomy 18p
- Thanatophoric Dysplasia – Type 1
- Thymic Carcinoma
- Transplant Coronary Artery Vasculopathy
- Tricuspid Atresia
- Trisomy 9
- Turnpenny-Fry Syndrome
U
- Ullrich Congenital Muscular Dystrophy
- Ureter Cancer – with Distant Metastases or Inoperable, Unresectable or Recurrent
- Usher Syndrome – Type I
- Uveal Melanoma – with Metastases
V
- Ventricular Assist Device Recipient – Left, Right, or Biventricular
W
- Walker Warburg Syndrome
- Warburg Micro Syndrome
- WHO Grade III Meningiomas
- Wolf-Hirschhorn Syndrome
- Wolman Disease
X
- Xeroderma Pigmentosum
- X-Linked Lymphoproliferative Disease
- X-Linked Myotubular Myopathy
Y
- Young-Onset Alzheimer's Disease
Z
- Zellweger Syndrome
- Zhu-Tokita-Takenouchi-Kim Syndrome
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